I took one pill and ended up in ER with pain so bad through chest, back and stomach that I could not move. My liver levels were off the chart (10X higher than norm), causing my doc to call on Monday after she got the ER triage report. nobody believed it was the macrobid at the ER, and even my doc was skeptical until she looked at my blood test results from 2 mos prior and saw that indeed my liver levels are normally fine. Confirmed with a test that showed them coming back down over the course of a month. Then she found out that a side effect is hepatitis. gee makes perfect sense. why listen to me? Had I been physically able to finish course of treatment, my liver would have been destroyed.