The first time I went on Wellbutrin, I had a really bad reaction ...

Hi, I'm taking both Prozac (60mg) and Wellbutrin SR (150mg) each morning for about 6 months now. It took many trials of other drugs before I found this combination to work best. Whatever initial side-effects I had with either of these (esp. insomnia, trembling) passed, and I feel more ME than I have in the last 5-6 yrs.! And, ya, if I suddenly go blank while in conversation, it's usually not some important thing, and I get to laugh at myself ---MUCH better than depression, when I avoided socializing. I rediscovered my humor and love life again! My personality is back! .

...Over this weekend, however, I finally ended up in ER due to these "crashing nap attacks" with "head-in-vice-headaches" I've been having more frequently (from about 1-2/mo. last year to 4-5/WEEK. over the last 2 mos). I'm a happy productive optimistic person, then suddenly I'm disabled. I stayed in close observation over the weekend, the neurologist determining I have migraine disease. From initial googling, it seems very common for migraine with aura (warning signs) to relate to MDD with anxiety (my condition). ...Now, on top of Prozac and Wellbutrin, they want to give me Depakote or Topamax (which I think I prefer), but I can't get CLEAR information as to how these drugs would work together. The doctor said with a low dose of Depakote or Topamax, he doesn't see any interference problem.
- - - Does anyone else out there suffer Migraine PLUS Major Depression with Anxiety? I'm hoping that since these are commonly linked dis-ease/-orders, that there would be some common treatments?