Taking Doxycycline hyclate for bacterial infection. I am on day 6 and the headaches are getting worse. I woke up last night at 1 AM and felt Nausea and a severe headache. I have to take this with a small meal or I will be in the bathroom until my next dose. I have diarrhea, headaches, DEPRESSION, no patience with my kids or wife, no sexual feelings, tingling lips that are starting to crack in the corners, dry mouth and no energy to do anything. I feel better on it, then I did without taking it, but If this does not take care of the so called bacterial infection, then I will be asking for a different MED next time. This stuff is very tough on you and if you can get something with less side effects, GET IT!