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My psychiatrist started me on Topamax 2 yrs ago for depression fr...

Posted at 9:54 PM on Jul 29, 2008 by manerva, #32864
My psychiatrist started me on Topamax 2 yrs ago for depression from being 75 lbs overweight. Started at 25 mg/day up to 50/day for 2 yrs. Lost 70 lbs and kept off with only minor side effects. Also took 150/day Wellbutrin during this time. (For being kind of a neat freak and washing my hands a lot.- didn't affect my social or work life much) Have slowly started gaining the weight back (+12 lbs). Seem to have built up an immune to the 50/day dosage over the 2 yrs. So he added 25 in the am in addition to the 50 I've been taking in the evening. (1 mo. ago) Having some strange reactions. My memory seems to be taking a real hit. I am a CPA (passed these exams 15 yrs ago) and now I'm studying for the Cert.'d Internal Auditor exams. I am having a great deal of trouble trying to memorize for these 12 hour long tests! I feel fatigued every day. My blurred vision (that requires reading glasses) has gone crazy. I can't read the song book at church at all. And I'm only 47!. I've had acne like bumps all around my nose and face. How could such a slight increase cause so much change? Also sometimes my heart feels like it is going to beat out of my chest. And I'm losing patience w/my 13 yr old son who's pushing my buttons to see how much he can get away with. He seems to sense that I'm not at my best. But if I go off this Topamax and gain back my 70 plds I know I will plunge into a DEEP depression. Has any one talked to their doctor about the possibility of these side effects going away after time? My tingling hands and feet did and my slight hair loss did. And my weight loss is trying to go away but I don't want that. I'm majorly concerned about the memory loss and blurred vision eventually going away. DALIAL
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Reply about 1 year ago on Aug 12, 2008 by awrytur, #11046

I was on Topmax for a couple of years. I was pleased with the side effect of losing weight (I was on it for bipolar/atipical), but I began losing my hair, too, and that never seemed to stop. Over time, my mind became fuzzy. I couldn't remember things -- even using the right word sometimes was difficult. I couldn't read because nothing seemed to sink in. I thought I was in early Alzheimer's and it scared me to death. I coudn't remember how to spell words and typing was a real struggle (which was really bad for me because I write for a living). My weight seemed to level off and the tingling in my hands and feet went away, but the fuzzy thinking and trouble with words/typing seemed to get worse. I had to get off of it. IIt's been a couple of years now. I have pretty much maintained my weight loss, but I do watch what I eat and the scales to see where I'm at. That can be difficult, but nothing compares to not being able to think straight. As someone else wrote on this site, everything has side effects -- everything. There is no "free" ride. Sometimes we need medication to straighten out the wiring in our heads, but it also takes working on oneself to find other ways of coping.

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