I have been taking Vytorin for approximately 8 months. I noticed that my knees were weak and I had cramps not only in my thighs but also my hands. I can hardly stand up from a sitting position. I thought it was because of the normal aging process. I am a Nurse and started to look at the medications I was taking. I decided that Vytorin could be the culprit. So 1 week ago I stopped taking it. I see some improvement in my knees and cramps. I did have problems with Lipitor in the past. I will not take any more Statin drugs. It is ridiculous to have such side effects from a drug that collegiately is suppose to help you. My cholesterol is around 200. I will seek other avenues to lower my cholesterol.