I have been on Ortho-Tri Cyclen lo for about 5 years off an on. When I first started the pill I was fine but after being on it for about a year everything changed. Before I started the pill I was losing weight. I was 163lbs and I got down to about 142lbs which was great but since then I've been on constant weight gain, I've tried metabolite and aerobics, some diet changes and now I last weighed 187lbs, with a few drastic changes I think I've dropped about 3 lbs since then. My sex drive used to be fairly high now it doesn't exist, I'm moody and always have headaches. I get nauseous a lot. So as of today I'm just going to quit the pill and live with cramps.