Hi there, Make sure to check with your OB on what type of enema is okay for pregnant women. I checked into using that when I was on Zofran, but was told some are okay and some can cause contractions and should not be used. Hope you are feeling better. When I stopped taking the Zofran and decided I would cope with being sick for the rest of the pregnancy, I changed my pre-natals and also went to acupuncture for the nausea (someone who was used to working with pregnant people) and between the two I felt better.