I was on a combination of Seroquel and Depakote. My doctor took me off Depakote and increased my Seroquel from 300 mg to 600 mg to compensate. The first time I took the 600mg dose I ended up in the emergency room because it paralyzed me! My blood pressure was 80/40.
And, to add insult to injury, I had to eat the $750 ER bill because my health insurance disallowed it.