I have been diagnosed with minimal change disease and have been taking 60 mg of prednisone daily for 2 months. I still have two months to go before the doctor will taper off. I feel like I am jumping out of my skin all the time. I am so irritable my family can hardly stand being around me. Other side effects are muscle aches, cramps, excessive facial hair, and weight gain. This is a miserable feeling. Yet my blood work shows that prednisone is "fixing" my kidney problem, so I have no choice but to stay on the drug. Find a good doctor. I have one of the best. He is doing everything to help prevent thrush (swish and spit medication twice a day), to prevent infection (antibiotic 3 times a week), and has now made a referral to a rheumatologist due to bone density results. Good luck to everyone who is taking this powerful medication!