I have been on 50mg zoloft for just three days, to treat depression, lethargy, shyness, and indecision. I had lost interest in exercise, sex, and my job. I take it at breakfast. I do feel some nausea in the morning, and i feel a little peculiar--but it's normal for me to feel peculiar, so no big deal. I think zoloft is going to work and be ok. I'll wait a couple weeks and see.
In the past i had a terrible, nauseating experience with Lexapro, but I've asked around and most of my friends take zoloft with no problems. All I want is a little boost of optimism so i can get out of this rut and on with my life. I've been depressed on and off for 10 years and I'm wasting my life.