I have had a wonderful experience with this medication. I have been on it for over 3 years at 75mg a day taken in the am. I have a few minor issues with going to the bathroom but by 9am I am feeling fine. I have been on many other depression meds and they all had terrible side effects, but with effexor I have had no issues. I am thankful to be on this medication and not so depressed all of the time. It also has helped with my GAD.