Please add me to the list of people with an extremely adverse reaction to Singulair. I had been taking 10 mg Singulair since 2005 after sinus surgery In June 2008 after returning from vacation I didn't get my prescription refilled in a timely manner and went without it for ~one week. In July I got a new prescription filled for Singulair and also began taking Advair Diskus 250/50 and AllegraD after an increase in asthma symptoms. I first thought the anxiety attacks were from the AllegraD as the "D" is for decongestant and contains psuedo-epinipherine. But the anxiousness continued and got worse after stopping the AllegraD. I then stopped taking the Advair (and also a nasal spray that I use called Flonase also since 2005) but was still in a major depressive episode with daily thoughts of suicide. It wasn't until I stopped taking the Singulair on August 23 that I started to return to normal. My normal does include a history of depression for which I take 10mg Paxil daily. Like the post from the psychiatrists wife noted, I am not sure if there is a direct scientific connection between these events. I do know that I never want to go back to that place I was in. I am shocked at the speed with witch I started to feel good after stopping the Singulair. I still have low grade sad feelings but I have stopped planning my own death. I always took my dose of Singulair in the morning and ~one hour later would begin to feel anxious. My evenings were tolerable with emotions slightly better. I simply stopped taking the medication without tapering and I am beginning to deal with what happened to me. Thank you all for sharing. Thank you.