the samples from the doctor worked great! started a new bottle of another 3 months supply, and BS went to 400! a week ago, started to get hives every 3-4 days.now, every day at night, 12 hrs. after taking Januvia, hives break out on back. waist, buttocks, arms.was in ER yesterday, they said rash from Januvia unlikely, because they HAVEN'T SEEN IT BEFORE. After insulin injections, BS only got down to 295. Afraid to eat, 9 hrs. later had a tomato and cucumber sandwich, and BS went back up to 360. My doctor added Metformin to Januvia, and I am now once again with horrible diarrhea, after only one dose of 500mg Met. BS is still sky high, and the ER didn't seem too concerned. Anyone ever hear of hives from Januvia? HELP!!