I've had migraines almost all my life. I've tried numerous meds but have found that Fiorcet helps the most. The only problem with it is that it is somewhat addictive and I've built a tolerance to it. So, recently my dr. prescribed Midrin. I've been taking one a day for the last 3 days and am experiencing terrible side effects - nausea, confusion, extreme fatigue, tiredness, laziness, lack of motivation and, worst of all, my headaches have gotten worse!!! I'm waiting on a call-back from my dr. on what to do but I can't imagine this medicine possibly working for me.