I got my Mirena inserted in February. I only had pain for the first month's period but I spotted constantly for 3 months. My mood went from 1 day of weepy PMS to as of September - 3 weeks of complete depression, moodiness, anger and I even had 2 days where I was completely not able to function. I've put on 20 lbs and even that was a fight to keep it to that. I had it removed yesterday and my Dr. said it couldn't be the Mirena because it is supposed to be non-systemic and in the 4 years she has been using it, no one has asked to have it removed. She also told me that it could be other hormone issues and she hopes the depression doesn't clear up otherwise she'll be mad that the Mirena caused it. I'm pretty sure that is what has caused it and I will prove it.