Reading some of the other side effects (after posting my most recent side effects) has made me think back a long time to when I was about 10 or so, and my asthma had been acting up- I was given a sort-of high dose of prednisone. For about two-six months after taking it, I had really severe knee pain, sometimes where I couldn't even walk around the grocery store. Eventually, it went away, and I distinctly remember my mom asking my doctor a few years later if it could be the cause (too high a dose and no weaning off), and the doctor said it was possible. Sometimes, I will have general knee pain for no specific reason, but luckily it doesn't happen very often.