Hi- I was on Lopressor 50mgs. twice a day for my slightly elevated BP, MVP, SVT, palpitations, and anxiety attacks. Started having some intermittent chest pain (not bad, just annoying). Dr. switched me to Toprol XL 100 mg/day. Of course, insurance made me get Metoprolol ER 100 mg/day (the generic) but I haven't had a problem with it!! I love taking just 1 pill a day instead of having to juggle the two pills and remembering if and when I took them. I take the pill every morning with breakfast (which is usually an apple and a small bowl of cereal and a glass of water). I have gained some weight since being on the Lopressor, but I started the Dash Diet and have lost about 8 lbs. in about 4 months, not too good but I'm not following the diet as well as I should be! I also get tired and occasionally have problems with hearburn and gas, but anytime you take any kind of medication you will have side effects. Wish I didn't have to take any meds but am not willing to subject myself to the effects of high blood pressure, I would rather have the side effects from the meds. My BP is usually 110/75 now and my heart rate is around 70-75. I'm 47 years old and feeling like I might make it into my 90's now!!