Hello, I started taking 100mgs twice a day three weeks ago for severe acne on my back and shoulders. (I am 40 have adult acne or back acne that never goes away) I just wanted to mention though that all of a sudden I noticed DEPRESSION and it took me awhile to realize that the Doxycycline was the only thing that was new. I have had bad depression before and am very familiar with it but it was completely gone. So, I am happy to see that maybe this med has caused others to get depression too. The nausea is nothing compared to mood disorders. My doctor said to stop taking it.