I was put on PredniSONE for my asthma. On day two of taking it I started to feel really awful. I couldn't lay down, sit down or stand without feeling like I was going to explode. So hubby took me to emergency. My blood pressure was sky high. 201 over 90, they put me on a fluid retention iv drip. I had retained way to much fluid and it made my blood pressure go skyhigh.