Taking nicomide while taking Celexa and a b-complex for hair and nails. I read somewhere that nicotinamide may have anxiolytic effect. Not sure if this combination of vit B3 along with the other B vitamins and an SSRI is causing the SSRI to be less or more effective, but have experienced I think a tranquilizing effect, more noticeable at night. But at the same time I feel some depression and anxiety so I wonder if the Celexa concentration is being decreased secondary to the vitamins. I will stop taking all B vitamins for a few days and see how I feel. My work environment lately has been more stressful, too, so it's hard to say what exactly is going on. But will stop all B vits and see how I feel.