After a year and a half of synthroid because of removal of my thyroid for cancer, I feel worse than I have ever felt in my life. Many tests have shown that there is no recurrence of the cancer. I would think I had fibromyalgia if it weren't that I read the blogs from other sufferers like me. I now take 150 mcg on most days. Some days I have to cut it down or skip it because I just cannot bear the body pain, weakness, brain fog, constant awakening in the night, severe cramping knee and leg pain, and muscle aches (there's no word strong enough to describe this pain -- 'aches' just doesn't do it). On the days I don't take synthroid I begin to feel like my old self. But my old self was 40 pounds thinner and losing. My old self walked three miles a day and hiked into the back country with my son. And my old self felt energetic and woke up every day with happy plans. Now I feel like an invalid. Some days I can barely walk. I cannot stand for longer than 5 minutes. I have tried cytomel, unithroid, and armour with varying problems. Synthroid is all that is left. Those of us who are dependent on this drug really need some good research on its effects. And we also need compassionate physicians who do not dismiss our pain and, it is not overdramatic to say, suffering.