I never thought an allergy med would have a reaction with my esophagus, but I guess everyone can discover something new! I used to be on RX Zyrtec many years ago and never really noticed any issues with it...I have taken Claritin OTC for some time now, but it doesn't seem to last long enough to cover the 24 hour day as it says, so I decided to try the Zyrtec OTC...by the third day I seemed to be having very tight and sharp esophageal pains in the middle of my chest and for the whole week I was on Zyrtec, the symptoms continued and became very intense...I stopped Zyrtec 3 days ago and have noticed a VAST improvement in the pain diminishing and I wondered if anyone else has had any of the same issues as I faced with this!