I have been on Advair for a little over two years. At first I thought it was very helpful, I had a very rough summer last year and it was the only thing helping me. But lately I've noticed an increase in frequency of my migraines, muscle cramps, constant edema in my legs and always being tired. My sleep is broken due to leg cramps, back spasms, or very strange dreams. I had also gained a lot of weight, but thought it was just natural slowing of my metabolism due to age (I am 46). I am cutting back to one dose a day and plan to stop altogether soon. I also stopped my Zocor because that seemed to make my leg swelling worse and the lasix the doctor prescribed just made me pee a lot and my legs were just as swelled up as before.