Updating - I am female in my sixties. started Simvastatin in Jan. this year due to 7.8 cholesterol reading. Came off for 3 months in May due to joint pains etc. GP said to try and lower cholesterol by diet. Practically lived on salads and fruit - however my cholesterol went up to 7.8 again. Proof to me that diet made no difference to my cholesterol reading. GP in August upped my dose then to 40mg a day. Felt very nauseous and ill and after 10 days came off yet again. I suggested to my GP high dose was making me ill. She agreed to my taking 10mg daily. Feel OK but still have joint pain. I have just read Doctor Malcolm Kendricks Book - The Great Cholesterol Con and I recommend it to all Simvastatin users. Very thought provoking. Please contact me if you would like more info.