Wow! I thought most of this was in my head! I keep telling my husband that this medication's side affects are almost as bad as the Crohn's flair ups! I, too, have had weight gain, increased appetite, mood swings, insomnia, night sweats, hair loss, hair growth on my face, leg cramps, depression, moon face, swelling around my neck (and ankles and abdomen)...in fact, you name a side affect and I probably have it. Currently, I am on 20 mgs (tapered from 40 mgs for 4 months). It seems like the side affects have increased as I have decreased dosage. Has anyone else noticed this as they decrease?