I am 22 years old. I have stage III endometriosis. I had my first of six shots two weeks ago. Honestly, I have mild cramping once in a while, but that was like that before the shot. I have not really had any significant side effects. My doctor gave me a prescription for hot flashes the first day I had my shot. The prescription is ergotamine 0.6mg/belladonna 16 mg/ phenob 40mg. I take it twice daily. I fell really good, except for feeling a little more tired from the prescription for hot flashes. For me, lupron has been no big deal. I guess I have been lucky.