I have experienced, avascular necrosis of both hips (resulting in total hip replacements) and avn of both solder (this time it resulted in partial shoulder replacements) Not to mention as everyone else has the thin skin, the weight gain. I have been on prednisone for 8 years - it is part of my immune suppressant cocktail that I take everyday. I have been on 4mg for approximately 5 years. It's very hard to lose the extra weight, the moon face lessens after a time but it is hard to tell because of the weight gain.