Cymbalta has been a lifesaver for me. There is one annoying thing...

Cymbalta has been a lifesaver for me. There is one annoying thing though... constipation. It's probably due to my other meds. as well but it is well worth the "effort" to stay on it. I have tried virtually every anti-depressant out there. I've had allergic reactions to many medications that have left me with proximal muscle damage (muscles closest to your body) and during the 10 years I was on Lithium (the first and major cause),. then cholesterol meds. such as statins, I had to have several surgeries to fix what muscles were breaking down (total rotator tear from simple exercise). Anyway, all this to say I had severe depression, was officially un-diagnosed bipolar, got off the statins, Lithium and got somewhat better. Then three other meds. did this to me so my body really reacts strangely to meds. Cymbalta has really helped me to function and not want to just die. Stay on it if you can. There aren't many better choices out there.(I asked to be put on the highest dose 300 mg 1 per day to see if I'd get the muscle pains that start at the top of the thigh and shoulders)