I have had to use Prednisone off and on since the 80's for flamation of the lungs when I get a cold. I didn't use it too much, however, until this last year and can't seem to get off of it. I need to finalize reconstructive surgery and have to keep postponing it due to the fact, I can't seem to get off the drug. My surgeron will not operate while on it. He says I need to be off 4 to 6 weeks. I had been off two weeks, when I got sick again last week w/a fever, upset tummy and chest discomfort. My lower legs are also very weak, which they were back in Dec. when I was sick. My pulmonary doesn't know why the leg weakness, but everything I read says Prednisone can cause weakness. I have asthma also.