I am a 62 year old, post menopausal woman. I had two shots of Kenalog in my right knee about a month apart in August and September 2008. The first did little to diminish the discomfort. The second shot did reduce the pain. Then without any sensation or warning, I started to bleed vaginally about a month later. It really scared me. My doctor suggested there might be a correlation to the cortisone shots I had received a month prior. The doctor administering the shots said he had never heard of that. He also said the drug left your system in a matter of days. I doubt that. My pelvic ultrasound was supicious so now I must have an endometrial biopsy. I did ask if there were side effects to the shot and was told no.