I am a physician and a patient. I have been on singulair and advair for several years now and had weight gain, anxiety, depression, and mild improvement in asthma that I could tell. I had pneumonia 4 times last year and thought it was the environment. I left the Midwest and moved to the east coast where I stopped my meds for several months and all the above symptoms resolved. I recently restarted them several weeks ago do to increase in symptoms and anxiety/panic attacks came back with a vengeance I stopped them and switched to other meds and wow the side effects are improving again. I am not going to take them or prescribe them again.