November, 2008 I started Januvia about 3 months ago while also taking metformin, glimeride. I previously took Actos but was gaining a lot of weight. Actos replaced the Avandia. The first few weeks on Avandia I seemed fine and the bs was okay. Gradually it increased along with severe painful spasms in my legs, trunk and daily in my neck. Eventually my hands began cramping. I also became severely constipated which is quite unusual for me. I then developed a series of upper respiratory infections. Since I was feeling awful I decided to research Januvia and its side effects. The manufacturer mentions the infections but not the others. As an experiment, I stopped taking the Januvia and within about 5 days, the painful leg/trunk spasms began to disappear. I'm contacting my doctor this week to find me a new drug....hopefully not insulin.