I have been taking the XR 30s for about 10 months. I get the right eye twitching, but this is just started recently. Also, the crash I experience in the late afternoon when I am coming home from work is unbearable. Before that, I was taking the generic Adderall tablets (they were blue) and they didn't work very well. Before that I was taking the peach Adderall (not XR) a couple a day that amounted to about 30 mgs and tht seem to work the best. I am going to ask my doctor to go back to those I think. You are correct, they do work in helping you to stay focused, but there do seem to be a lot of side effects. I did not get these side effects when I first started on the medicine.