my 95 yr. old mother was given 2 SMZ/TMP pills 12 hrs apart and within hours after the 2nd one, spiked a fever and became flush around her eyes and then her entire face. She ended up in the emergency room. Several days later she broke out with hives, red blotches, arm bruises, a skin infection, and blood vessel breaks on her arms and legs. She also itched terrible all over. Doctors thought it was her blood platelets causing this but they were wrong. She is allergic to sulfur drugs. Finally after 5 weeks now she seems to be improving. This is a very dangerous drug for some.