I had impetigo on my ankle that came about from an insect bite. I had been putting mupirocin on the sore, but it hadn't cleared up in two weeks, so the doctor switched me to bactrim. well, within 10 hours of my first dose, I had a low grade fever and incredible aches in my head. I called the office and the nurse told me to stay on the bactrim since I probably was just coming down with a viral infection or something. I stuck with it, but every day, my temperature rose 1 degree, and the pain was something fierce. Finally on the 5th day, my temperature was up to 103, yet I had NO respiratory infection. I just stopped taking the bactrim and within 24 hours the fever is gone, but I'm still sore. My ankle still hasn't cleared up either! Worst experience of my life.