I have been having difficulty with my legs from the knees down since taking Remeron for over a year. Normal walking is a chore, but let me get in a department or grocery store and I am in such agony with leg pain from the knee to my ankles. It is a heavy, throbbing ache. Pain pills, heat and sleep is the only cure. Never had this problem before this. If I ween myself off them, my migraines come back with a vengence.