I was on the duragesic patch for 8 months, and it was a nightmare...Seems I was absorbing the medicine in the patch in 2 days, and going into 3rd day extreme withdrawals all along, but doctors did not recognize this, and kept upping the dosage, By the time I was up to the 75 mcg patch, I had lost 30 lbs and, later they tell me, was close to death.