Much like others, I was prescribed Bactrim for a UTI. I had only taken 2 pills before I noticed the strange blister/knot on the top of my tongue. I was terribly achy, but did not associate these symptoms as drug allergies as I have never been allergic to any antibiotic in the past. I went to sleep- weird dreams. Woke up and the "knot" had moved toward the base of my tongue, my neck/glands were sore, my speech was slurred due to the knot and the numb tongue. This site has been most helpful. I stopped the med and will not be taking it ever again.