I have been on Advair 2X a day for 2 weeks with a history of migraines. The last 3 days I have had 3 separate migraines with preceding scotomas- the third migraine headache on the third day- was the worst ever and didn't respond to migraine medicine. My husband figured out it was the Advair and I stopped the medication. For those with a history of migraines- don't take Advair as run the risk of severe migraine headaches.