I had excruciating muscle spasms in the legs when taking synthroid. My physicians argued that Synthroid or T4 was all that was needed because my body would produce T3. This simply is not accurate information for everyone. The muscle spasms became so severe that I went to the Cleveland Clinic in hopes of resolving this issue. This was a waste of time; the docs could only confirm the presence of muscle spasms in my legs and offered no other options. Finally, while reviewing all my lab reports and the related symptoms, I discovered that the muscle spasms only occurred when I was taking synthroid for hypothyroidism. I switched to Armour thyroid and the muscle spasms ceased. I urge everyone with hypothyroidism to find a doctor that can think outside the box.