Well, after reading all of the postings here, I feel like I just dodged a major bullet! I took Singulair for a little less than a week in combination with a couple of other meds to get a bout of uncontrolled asthma reined in. All was well for 4 or 5 days and then suddenly I began to itch like crazy - I had a massive outbreak of hives (and this was while taking Prednisone, which is used to TREAT hives). Well, long story short, the doctor felt that it was most likely the Singulair and told me to stop taking it. I did and did not have another outbreak of hives. Now I'm actually rather thankful to have gotten the hives if it meant getting me off this medication before it could cause more serious issues!