I had the Mirena inserted about two months after my second baby. ...

I had the Mirena inserted about two months after my second baby. I was not feeling any post-partum depression at that time, but my life was VERY hectic. I had never had a depressive episode before. After about four months of having the Mirena, I basically had a "nervous breakdown": deep depression and an inability to function in my regular life activities. Like I said, my life was very hectic at this point, but I want to point out that I had been heavily stressed out before in my life, with no depression. Anyway, my GP insisted on taking it out ASAP; she had heard that some women get depressed on Mirena (when they never had that type of problem before...). I went on Wellbutrin (still on it!), and am doing a lot better 12 months later. However, I'm still fighting the depression, and I have some anxiety, too. I'd say that if a woman has an experience like mine, the smart thing to do is have the Mirena taken out. You can always have it put back in later, if you want.