I've been taking Omeprazole on and off for 6 months. I've been feeling increasingly depressed, anxious and apathetic - unable to get out of bed in the morning and having difficulty concentrating. Had initially thought that I was feeling like this because of the adic reflux and ulcers... having read these posts I now think that it could be because of the pills themselves. I'm going to come off them immediately and stick to herbal supplements and controlling my diet.