i am 58 diagnosed with copd 2 years ago i was never sick and worked construction since 1969 but i did smoke 3 packs a day i thought my 30 lbs weight was from not smoking anymore im sure some is but not all of it i have been reading about the side effects other people have and i have more than i realized the worst besides the weight gain is the heart rate i recently was hospitalized for it if we are sick we need medicine but i don't know about this i have read about people who have stopped taking advair and then became worse when they had to go back it damed if you do and damed if you don't all i know is that i am retired and cant afford a $1000.00 hospital stay and now that i think about it i had two other 3 day stays in the hospital for lung infections and yes i get moody have headaches chest pains sore joints im on my way to getting old i don't think all those things are from age i think the advair has to go good luck