Nausea is the only side effect I have noticed after taking 300 mg of Wellbutrin for over three years now. The nausea is worst in the morning, after I take the pill. My stomach feels very acid, like I just drank a pot of coffee with no breakfast. It usually gets better if I eat something, although not always.
For the first few years, I also experienced decreased appetite - no complaints there! I lost weight, but this year I regained it. Not sure if the appetite suppression effect wore off, or if this year has just been really stressful for me.
I also found it impossible to smoke cigarettes - they tasted nasty. Another good side effect for me.
Overall, Wellbutrin has helped me with depression and social anxiety. Best of all, I have absolutely no sexual side effects, unlike with every other antidepressant I have tried.