I've been taking Januvia for about 2 months and have experienced sever constipation. I don’t seem to have an urge to have a BM. I have increased my fiber and water intake with no success. I’m also taking Metformin, so I was used to having diarrhea. Since taking the Januvia, I need to take meds to have a BM. I’m also experiencing numbness down the outside of my thighs. I have trouble sleeping throughout the night and I’m very anxious. I don’t know if my problem in the Januvia, but I do know that I did not have these problems until I started taking the Januvia. I’m planning to stop taking the drug for a few days and see how I feel.