Has anyone experienced anal fissures? Since Advair has mucus for...

Has anyone experienced anal fissures? Since Advair has mucus forming as one of it's side effects my husband and I were curious to see if anyone else was reporting weeping around the anus which is causing very painful skin irritation and a fissure. He also has terrible leg cramps while sleeping at night, hair loss, mouth sores, thrush in his throat. He has been on advair for over two years and we are now reading of all the same side effects that have been plaguing him for some time now. The anal fissure is difficult to discuss, but I did read of a mother below that wondered if her son's soiled underwear could be related. Does anyone else have this symptom?