I have been on Welchol for 5 months and it has changed my life. It was prescribed for IBS and I have tried many different medications, acupuncture, naturopathy, yoga, and anything else that the doctors hinted would help. This is the first thing that seems to be working. Since August, I have had four "flare-ups," which is a significant difference. I have been experiencing more headaches and some gas and heartburn. In my case, I am willing to accept these side effects because my quality of life has improved SO much in the past five months. I know that everyone experiences different side effects and results, but if you've tried everything and feel burnt out and like you want to give up, I recommend just trying Welchol to see if it can help you.