Researchers have been doing studies for many years regarding tryi...
| Posted at 3: 2 PM on Feb 03, 2009 by concernedcitizen, #38627 |
Singulair most reported side effects and reactions by year
Year Description Frequency
2004 ALLERGIC GRANULOMATOUS ANGIITIS 66
ABDOMINAL PAIN 7
ALANINE AMINOTRANSFERASE INCREASED 6
ASTHMA 6
CONVULSION 6
2005 ALLERGIC GRANULOMATOUS ANGIITIS 148
ASTHMA 18
ALANINE AMINOTRANSFERASE INCREASED 11
ABDOMINAL PAIN UPPER 10
ATRIAL FIBRILLATION 8
2006 ALLERGIC GRANULOMATOUS ANGIITIS 129
ASTHMA 28
CONVULSION 19
ABORTION SPONTANEOUS 14
ALANINE AMINOTRANSFERASE INCREASED 12
2007 ALLERGIC GRANULOMATOUS ANGIITIS 111
ASTHMA 29
CONVULSION 17
AGGRESSION 13
STEVENS-JOHNSON SYNDROME 11
2008 ABNORMAL BEHAVIOUR 232
DEPRESSION 147
ANXIETY 115
SUICIDAL IDEATION 90
AGGRESSION 81
These are reports to the FDA by year,isnt it possible all these side effects are some form of vasculitis,the number one reported side effect for years ??????
flindy,
You comment was made through keen observation. I tend to agree with you that vasculitis is possibly connected to Singulair adverse side effects.
My opinion is that Singulair and nitric oxide is the key issue. Excessive production of nitric oxide due to adverse reaction to Singulair could cause vasculitis - meaning vasodilation/constriction and severe inflammation.
This is quoted from research on vasculitis.
"Cells of the vasculature play a central role in physiology and pathology. Endothelial cells control platelet adhesion, maintain a balance of fibrinolytic and prothrombotic activity, regulate vascular tone and play a critical role in regulating the recruitment of leucocytes into inflammatory sites Regulation of vascular tone is dependent on the production of vasodilators, such as nitric oxide (NO) and prostacyclin, and vasoconstrictors, such as endothelin. While cells of the vasculature (such as endothelial cells and platelets) have been proposed to be the major producers of vasoconstrictors and vasodilators, it is now becoming clear that stromal cells such as fibroblasts and smooth muscle cells can also produce biologically active proteins that act in a paracrine manner to regulate endothelial cell function."
I really don't think the FDA wants to know how Singulair works. They always just look at clinical data. As in every study or experiment, the answer you get depends upon what you are looking for. Until the FDA wants to research how Singulair works and why patients have adverse side effects, then we just observe and speculate.
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