Have Panic Disorder..put on Zoloft 100mg. Used to weigh 125lbs but now I weigh 160. Maybe the panic attacks were better. at least I was at my normal range. Panic attacks made me throw up 3xs a day. caused other problems with my esophagus. don't know if any other meds would help. scared to try. I work out everyday...swimming, hiking, etc. nothing gets the weight off.